Dr. Rodolfo A. Martinez


Department of Chemistry and Forensic Science
New Mexico Highlands University
Las Vegas, NM 87701

Research interests include the design and synthesis of isotopically-labeled compounds that ware very useful in all fields of science. This work has resulted in several patents and publications in the areas of bioscience, metabolism studies, quantum compund, and forensic science.

Phone: 505.454.3155
Room:HSCI-132
Email: rudy@nmhu.edu

Scientific Degrees

1892:
Univ. of Texas at San Antonio, San Antonio, TX - B.S. (Chemistry)
1992:
Univ. of Texas at San Antonio, San Antonio, TX - M.S. (Synthetic Organic Chemistry)
1993:
Baylor University, Waco, TX - Ph.D. (Physical Organi Chemistry)
1993-1996:
Los Alamos National Laboratory, Los Alamos, NM - Postdoc (Synthetic Chemistry)

Professional Experience

2005 to present:
Research Professor, Natural Sciences, New Mexico Highlands University
2005 to 2007:
Scientific Advisor, Spectra Stable Isotopes
2001 to 2005:
Principal Investigator, Centers for Disease Control (CDC) Stable Isotope Program, Los Alamos National Laboratory, Los Alamos, NM
1996 to 2005:
Staff Member, Bioscience Division, Los Alamos National Laboratory, Los Alamos, NM
1993 to 1996:
NIH Postdoctoral Fellow, chemical Science and Technology, Los Alamos National Laboratory, Los Alamos, NM
1993 to Spring:
Lecturer, Chemistry Department, Baylor University, Organic I and Organic Laboratory, Waco, TX
1989 to 1993:
Teaching Assistant, Chemistry Department, Baylor University, Waco, TX
1981 to 1982:
Research Assistant, Department of Biochemistr, University of Texas Health Science Center, San Antonio, TX

Honors and Awards

1982 to 1984
Graduate Intern, Minority Biological Support Program (MBSP), University of Texas, San Antonio, TX
1984 to 1985
Predoctoral Fellow (Robert A. Welch Foundation), University of Texas Health Science Center, San Antonio, TX
1993 to 1996
NIH Minority Postdocatoral Fellow, Los Alamos National Laboratory, Los Alamos, NM

Journal Articles

Selected peer-reviewed publications (in chronological order)
1. Hodges, J. S.; Cappellaro, P.; Havel, T. F.; Martinez, R.; Cory, D. G., Experimental implementation of a logical Bell state encoding. Physical Review A: Atomic, Molecular, and Optical Physics 2007, 75 (4).
2. Asani, E. M.; Khrustalev, V. N.; Williamson, R. M.; Martinez, R. A.; Unkefer, C. J.; Timofeeva, T. V., Stereoselective Synthesis and X-Ray Structure Determination of Labeled [1, 2, 3-13C3]-1-(Phenylsulfinyl)-3-Benzyloxyacetone. Journal of Chemical Crystallography 2007, 37 (10).
3. Asani, E. M.; Khrustalev, V. N.; Juarez, E.; Martinez, R. A.; Timofeeva, T. V., S-Phenyl N,N'-dimethyl-13C2-thiooxamate. A by-product in the synthesis of ethyl N,N'-dimethyl-13C2-oxamate. Acta Crystallographica, Section E: Structure Reports Online 2007, E63 (4).
4. Asani, E. M.; Glass, D. R.; Martinez, R. A.; Timofeeva, T. V., (S)-N-(Phenylsulfanyl-[1,2-13C2]-acetyl)-2,10-camphorsultam. Acta Crystallographica, Section E: Structure Reports Online 2007, E63 (8).
5. Wenzel, S. C.; Williamson, R. M.; Gruenanger, C.; Xu, J.; Gerth, K.; Martinez, R. A.; Moss, S. J.; Carroll, B. J.; Grond, S.; Unkefer, C. J.; Mueller, R.; Floss, H. G., On the Biosynthetic Origin of Methoxymalonyl-Acyl Carrier Protein, the Substrate for Incorporation of "Glycolate" Units into Ansamitocin and Soraphen A. Journal of the American Chemical Society 2006, 128 (44).
6. Henry, M. K.; Emerson, J.; Martinez, R.; Cory, D. G., Localization in the quantum sawtooth map emulated on a quantum-information processor. Physical Review A: Atomic, Molecular, and Optical Physics 2006, 74 (6, Pt. A).
7. Barr, John R.; Moura, Hercules; Boyer, Anne E.; Woolfitt, Adrian R.; Kalb, Suzanne R.; Pavlopoulus, Antonis; McWilliams, Lisa G.; Schmidt, Jurgen G.; Martinez, Rodolfo A.; Ashley, David L., Botulinum neurotoxin detection and differentiation by mass spectrometry. Centers for Disease Control and Prevention, Atlanta, GA, USA., Emerging Infectious Diseases 2005, 11(10), 1578-1583.
8. Young, C. L.; Ash, D.; Driskell, W. J.; Boyer, A. E.; Martinez, R. A.; Silks, L. A.; Barr, J. R., A Rapid, Sensitive Method for the Quantitation of Specific Metabolites of Sulfur Mustard in Human Urine Using Isotope-Dilution Gas ChromatographyETHTandem Mass Spectrometry. Journal of Analytical Toxicology 2004, 28, (5), 339-345.
9. Boyer, A. E.; Ash, D.; Barr, D. B.; Young, C. L.; Driskell, W. J.; Whitehead, R. D., Jr.; Ospina, M.; Preston, K. E.; Woolfitt, A. R.; Martinez, R. A.; Silks, L. A. P.; Barr, J. R., Quantitation of the Sulfur Mustard Metabolites 1,1'-Sulfonylbis[2-(methylthio)ethane] and Thiodiglycol in Urine Using Isotope-Dilution Gas Chromatography-Tandem Mass Spectrometry. Journal of Analytical Toxicology 2004, 28, (5), 327-332.
10. Barr, J. R.; Driskell, W. J.; Aston, L. S.; Martinez, R. A., Quantitation of Metabolites of the Nerve Agents Sarin, Soman, Cyclohexylsarin, VX, and Russian VX in Human Urine Using Isotope-Dilution Gas Chromatography-Tandem Mass Spectrometry. Journal of Analytical Toxicology 2004, 28, (5), 372-378.
11. Pravia, M. A.; Boulant, N.; Emerson, J.; Farid, A.; Fortunato, E. M.; Havel, T. F.; Martinez, R.; Cory, D. G., Robust control of quantum information. Journal of Chemical Physics 2003, 119, (19), 9993-10001.
12. Tomson, F.; Bailey, J. A.; Gennis, R. B.; Unkefer, C. J.; Li, Z.; Silks, L. A.; Martinez, R. A.; Donohoe, R. J.; Dyer, R. B.; Woodruff, W. H., Direct Infrared Detection of the Covalently Ring Linked His-Tyr Structure in the Active Site of the Heme-Copper Oxidases. Biochemistry 2002, 41, (48), 14383-14390.
13. Martinez, R. A.; Alvarez, M. A.; Velarde, S. P.; Silks, L. A. P.; Stotter, P. L.; Schmidt, J. G.; Unkefer, C. J., Large-Scale Preparation of [13C]Methyl Phenyl Sulfide from [13C]Methanol by a One-Step Process. Organic Process Research & Development 2002, 6, (6), 851-854.
14. Laflamme, R.; Knill, E.; Cory, D. G.; Fortunato, E. M.; Havel, T. F.; Miquel, C.; Martinez, R.; Negrevergne, C. J.; Ortiz, G.; Pravia, M. A.; Sharf, Y.; Sinha, S.; Somma, R.; Viola, L., NMR and quantum information processing. Los Alamos Science 2002, 27, 227-259.
15. Laflamme, R.; Knill, E.; Negrevergne, C.; Martinez, R.; Sinha, S.; Cory, D. G., Introduction to NMR quantum information processing. Proceedings of the International School of Physics \"Enrico Fermi\" 2002, 148th, (Experimental Quantum Computation and Information), 411-439.
16. Stocking, E. M.; Martinez, R. A.; Silks, L. A.; Sanz-Cervera, J. F.; Williams, R. M., Studies on the biosynthesis of paraherquamide: Concerning the mechanism of the oxidative cyclization of L-isoleucine to b-methylproline. Journal of the American Chemical Society 2001, 123, (14), 3391-3392.
17. Li, Z.; Michalcyk, R.; Martinez, R. A.; Unkefer, C. J.; Silks, L. A., III, Synthesis of a model system for the putative histidine-tyrosine dimer found in paracoeeus denitrificans two-subunit cytochrome c oxidase. Recent Research Developments in Organic Chemistry 2001, 5, (Pt. 1), 41-48.
18. Knill, E.; Laflamme, R.; Martinez, R.; Negrevergne, C., Benchmarking Quantum Computers: The Five-Qubit Error Correcting Code. Physical Review Letters 2001, 86, (25), 5811-5814.
19. Knill, E.; Laflamme, R.; Martinez, R.; Tseng, C. H., An algorithmic benchmark for quantum information processing. Nature (London) 2000, 404, (6776), 368-370.
20. Cory, D. G.; Laflamme, R.; Knill, E.; Viola, L.; Havel, T. F.; Boulant, N.; Boutis, G.; Fortunato, E.; Lloyd, S.; Martinez, R.; Negrevergne, C.; Pravia, M.; Sharf, Y.; Teklemariam, G.; Weinstein, Y. S.; Zurek, W. H., NMR based quantum information processing: Achievements and prospects. Fortschritte der Physik 2000, 48, (9-11), 875-907.
21. Wu, R.; Orji, C. C.; Michalczyk, R.; Schmidt, J. G.; Li, Z.; Stocking, E. M.; Ashburn, D. A.; Kelly, J. A.; Khalsa, O.; Martinez, R. A.; Mariappan, S. V. S.; Unkefer, C. J.; Silks, L. A., Synthesis and application of labeled nucleic acids, amino acids and carbohydrates. Recent Research Developments in Organic & Bioorganic Chemistry 1999, 3, 1-27.
22. Martinez, R. A.; Silks, L. A., III; Unkefer, C. J., Synthesis of tert-butyl-[1-13C]glycolic acid. Journal of Labelled Compounds & Radiopharmaceuticals 1999, 42, (5), 505-508.
23. Wu, R.; Hernandez, G.; Dunlap, R. B.; Odom, J. D.; Martinez, R. A.; Silks, L. A., The use of the selenocarbonyl group both as a 77Se NMR reporter group and for stereoselective carbon-carbon bond generation. Trends in Organic Chemistry 1998, 7, 105-114.
24. Michalczyk, R.; Li, Z.; Orji, C. C.; Wu, R.; Martinez, R. A.; Unkefer, C. J.; Silks, L. A., Synthesis of stable isotope labeled nucleic acids and carbohydrates. Trends in Organic Chemistry 1998, 7, 115-121.
25. Peng, J.; Barr, M. E.; Ashburn, D. A.; Lebioda, L.; Garber, A. R.; Martinez, R. A.; Odom, J. D.; Dunlap, R. B.; Silks, L. A., III, Synthesis and Characterization of Acylated Chiral Oxazolidine-2-selones: Selone Chiral Derivatizing Agents for the Detection and Quantitation of Remotely Disposed Chiral Centers. Journal of Organic Chemistry 1995, 60, (17), 5540-9.
26. Acosta, C. K.; Bahr, M. L.; Burdett, J. E., Jr.; Cessac, J. W.; Martinez, R. A.; Rao, P. N.; Kim, H. K., Synthesis of unnatural amino acids. Journal of Chemical Research, Synopses 1991, (5), 110-11.
27. Martinez, R. A.; Rao, P. N.; Kim, H. K., An improved pinacol rearrangement for the synthesis of 2-alkyl-1,3-cyclopentanediones. Synthetic Communications 1989, 19, (3-4), 373-7.
28. Peterson, D. M.; Martinez, R. A.; Satsangi, N.; Weintraub, S. T.; Stotter, P. L.; Friedberg, S. J., Synthesis of regiospecifically labeled [18O]glycolic acid and [18O]acyldihydroxyacetone phosphate. Journal of Lipid Research 1988, 29, (1), 94-101.
29. Williams, R. F.; Mumford, C. L.; Williams, G. A.; Floyd, L. J.; Aivaliotis, M. J.; Martinez, R. A.; Robinson, A. K.; Barnes, L. D., A photoaffinity derivative of colchicine: 6-(4'-azido-2'-nitrophenylamino)hexanoyldeacetylcolchicine. Photolabeling and location of the colchicine-binding site on the a-subunit of tubulin. Journal of Biological Chemistry 1985, 260, (25), 13794-802.
30. Keenan, R. W.; Martinez, R. A.; Williams, R. F., Synthesis of [32P]dolichyl phosphate, utilizing a general procedure for [32P]phosphorus oxychloride preparation. Journal of Biological Chemistry 1982, 257, (24), 14817-20.

Patents

1. Martinez, R. A. Synthesis of phosphonic acid labeled compounds. 2009-421458
2009259064, 20090409., 2009.
2. Schmidt, J. G.; Kimball, D. B.; Alvarez, M. A.; Williams, R. F.; Martinez, R. A. Methods for preparing isotopically labeled compounds from substrates on solid phase supports or affinity tags. 2008-US7222
2008156582, 20080609., 2008.
3. Martinez, R. A.; Minton, M.; Anderson, F. E., III; Ortiz, E. G.; Tortolani, K. E. Synthesis of isotopically labeled α-keto acids and esters. 2007-US16209
2008011033, 20070711., 2008.
4. Martinez, R. A. Preparation of [13C]-methyl phenyl sulfide derivatives. 2008-98135
2008255370, 20080404., 2008.
5. Unkefer, P. J.; Martinez, R. A.; Knight, T. J. Use of pyroglutamate stereoisomers for improving plant growth and yield. 2005-269417
2007105719, 20051107., 2007.
6. Martinez, R. A.; Schmidt, J. G.; Alvarez, M. A.; Silks, L. A. Synthesis of labeled compounds. 2005-172126
2007004929, 20050629., 2007.
7. Alvarez, M. A.; Martinez, R. A.; Unkefer, C. J. Synthesis of [13c] and [2h] substituted methacrylic acid, [13C] and [2H] substituted methyl methacrylate and/or related compounds. 2005-268227
2007106085, 20051104., 2007.
8. Alvarez, M. A.; Martinez, R. A.; Unkefer, C. J. Process for preparation of 13C and 2H labeled methacrylic acid, methyl methacrylate, and intermediates thereof. 2006-591828
2007191635, 20061102., 2007.
9. Martinez, R. A.; Unkefer, C. J.; Alvarez, M. A. Synthesis of [1-13C]pyruvic acid, [2-13C]pyruvic acid, [3-13C]pyruvic acid and combinations thereof. 2005-52589
2006178534, 20050207., 2006.
10. Martinez, R. A.; Unkefer, C. J.; Alvarez, M. A. Synthesis of isotopically labeled R- or S-[13C,2H]glycerols. 2003-629982
2005027146, 20030730., 2005.
11. Martinez, R. A.; Unkefer, C. J.; Alvarez, M. A. Synthesis of isotopically labeled oxalic acid derivatives. 2003-456081
6753446, 20030605., 2004.
12. Martinez, R. A.; Silks, L. A., III; Unkefer, C. J.; Atcher, R. Synthesis of labeled metabolites of mustard gas. 2003-419310
6709645, 20030418., 2004.
13. Helvenston, M. C.; Martinez, R. A.; De Baca, J. C.; Juarez, J. J. Methods and systems for hydrazine remediation. 2002-211891
2004024251, 20020801., 2004.
14. Martinez, R. A.; Alvarez, M. A.; Silks, L. A.; Unkefer, C. J.; Schmidt, J. G. Synthesis of [2H1,13C], [2H2,13C] and [2H3,13C]methyl aryl sulfones and sulfoxides. 2003-342521
2003158445, 20030114., 2003.
15. Martinez, R. A.; Alvarez, M. A.; Silks, L. A., III; Unkefer, C. J. Synthesis of deuterium-and-13C-substituted dithanes. 2002-74669
6541671, 20020213., 2003.
16. Martinez, R. A.; Alvarez, M. A.; Silks, L. A.; Unkefer, C. J. Synthesis of [2H1,13C], [2H2,13C] and [2H3,13C]methyl aryl sulfides. 2003-342577
2003153789, 20030114., 2003.
17. Unkefer, P. J.; Knight, T. J.; Martinez, R. A. Use of proline derivatives for improving growth and useful properties of plants and algae. 2001-US1144
2001054500, 20010112., 2001.
18. Martinez, R. A.; Unkefer, P. J. Preparation of 2-hydroxy-5-oxoproline using Fremy's salt. 2000-584621
6288240, 20000531., 2001.